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KMID : 0385520170300060355
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Analytical Science & Technology
2017 Volume.30 No. 6 p.355 ~ p.378
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Analytical trends in mass spectrometry based metabolomics approaches of neurochemicals for diagnosis of neurodegenerative disorders
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Lee Na-Kyeong
Jeon Won-Jei
Jeong Seung-Woo
Byun Jae-Sung
Lee Won-Woong
Hong Jong-Ki
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Abstract
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Because neurochemicals are related to homeostasis and cognitive and behavioral functions in human body and because they enable the diagnosis of numerous neurodegenerative disorders, there has been increasing interest in the development of analytical platforms for neurochemical profiling in biological samples. In particular, mass spectrometry (MS)-based analytical methods combined with chromatographic separation have been widely used to profile neurochemicals in metabolic pathways. However, development of delicate sample preparation procedures and highly sensitive instrumental detection is necessary considering the trace levels and chemical instabilities of neurochemicals in biological samples. Therefore, in this review, analytical trends in MS-based metabolomics approaches to neurochemicals in multiple biological samples, such as urine, blood, CSF, and biological tissues, are discussed. This paper is expected to contribute to the development of an analytical platform to discover biomarkers that will aid diagnosis, prognosis, and treatment of neurodegenerative disorders.
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KEYWORD
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neurochemicals, profiling analysis, chromatographic separation, mass spectrometry, metabolomics approach
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